Novel dihydropyrimidines and its pyrazole derivatives: Synthesis and pharmacological screening

In the present study, we have synthesized novel dihydropyrimidines (1a–j), their dimethylated adducts (2a–j), and hydrazine derivatives (3a–j) of 2a–j and subsequently their pyrazole derivatives (4a–j). Elemental analysis, IR, 1H NMR and mass spectral data elucidated structure of newly synthesized compounds. Some of these novel derivatives showed moderate to potent in vitro antioxidant, anti-inflammatory, antibacterial, antifungal and anthelmintic activity.

Graphical abstractSynthesis of pyrimidine derivatives and its pyrazole derivatives. Few of the synthesized compounds shows potent antioxidant, anti-inflammatory, antibacterial, antifungal and anthelmintic activities. Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis of novel dihydropyrimidines and its pyrazole derivatives. ► Structural elucidation with elemental analysis, IR, 1H NMR and mass spectral data. ► Some of the compounds proved good antioxidant, anti-inflammatory, antimicrobial and anthelmintic activity.