| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397568 | European Journal of Medicinal Chemistry | 2011 | 7 Pages |
Abstract
⺠Angiogenic thymidine phosphorylase (TP) is a target for cancer chemotherapy. ⺠Virtual screening of NCI/ACD databases with TP identified imidazolidine inhibitors. ⺠A series of imidazolidines were prepared and their TP activity evaluated. ⺠The lead compound was 3-(2,4,5-trioxo-3-phenylethyl-imidazolidin-1-yl)propionamide.
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Authors
Mehdi Rajabi, David Mansell, Sally Freeman, Richard A. Bryce,