Efficient and novel one-pot synthesis of antifungal active 1-substituted-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines using solid support

A simple, efficient and environment-friendly procedure is developed for the synthesis of 1-substitued-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, p-TsOH as catalyst and basic alumina as solid support under microwave irradiation. The products are obtained in moderate to good yields and are in a state of high purity. Moreover, title compounds have been screened for antifungal activity.

Graphical abstractA simple, efficient and environment-friendly procedure is developed for the synthesis of antifungal active 1-substitued-8-aryl-3-alkyl/aryl-4H-pyrazolo[4,5-f][1,2,4]triazolo[4,3-b][1,2,4]triazepines in the presence of N,N-dimethylformamide as an energy transfer medium, basic alumina as solid support and p-TsOH as catalyst under microwave irradiation.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► I try to synthesize a new class of compounds which exhibit antifungal activity. ► These compounds are synthesized using non-conventional method of reaction activation. ► This one-pot synthesis involves the use of basic alumina as solid support and DMF as an energy transfer medium. ► This reaction is catalyzed by p-TsOH.