Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives

A series of 1,4-dihydropyridine derivatives (1a–g) were prepared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium hydroxide. A new series of compounds (2a–g) were prepared from compounds (1a–g) via reaction with thiosemicarbazide using the condensation method. The synthesized compounds were confirmed by IR, 1H NMR, 13C NMR, mass spectral and elemental analyses. The synthesized compounds (1a–g) and (2a–g) were also screened for anticoagulant properties.

Graphical abstractScreening for anticoagulant activity of 1,4-dihydropyridine derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch highlights► New series of 1,4-dihydropyridine derivatives were prepared and characterized from IR, 1H NMR, 13C NMR, mass spectral and elemental analyses. ► The synthesized compounds were screened for anticoagulant activity.