Synthesis and biological property of some novel 1,3,4-oxadiazoles

A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1′-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by 1H NMR, 13C NMR, 19F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity.

Graphical abstractA novel series of 5-[substituted-(1,1’-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and their S-alkylated derivatives have been prepared through a multi step organic synthesis involving palladium catalyzed Suzuki-Miyaura coupling. The new compounds have been screened for their antibacterial, antifungal and analgesic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide