| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397683 | European Journal of Medicinal Chemistry | 2010 | 5 Pages |
A series of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazolines were synthesized in one step by condensing suitably substituted propenones, hydrazine and acetic/propionic acid. The newly synthesized pyrazolines were characterized by analytical and spectral data. The new compounds were screened for analgesic and anti-inflammatory activity and most of them showed good activity comparable with that of standard drugs Pentazocin and Diclofinac sodium respectively.
Graphical abstractA series of pyrazolines were synthesized in one pot reaction by condensing propenones, hydrazine and acetic/propionic acid. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities. Figure optionsDownload full-size imageDownload as PowerPoint slide
