| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397765 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
Abstract
A series of 3-benzyloxy-1-aza-9-oxafluorenes has been synthesized and biologically evaluated as novel MDR modulators. The concentration dependent inhibition of the efflux pump ABCB1 (P-glycoprotein) has been characterized and is discussed in relation to calculated lipophilicity data. Instead of the molecular lipophilicity the exact positioning of functional groups was found decisive for the biological activities.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Martin Krug, Burkhardt Voigt, Christiane Baumert, Ralf Lüpken, Joséf Molnár, Andreas Hilgeroth,