| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397808 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani. Several compounds were found to strongly inhibit the proliferation of human cell line and/or parasites. The 4-(3,4-dimethoxyphenyl)-6,7-dimethoxycoumarin exhibit a potent activity on L. donovani amastigotes with a selectivity index (SI = 265) twice than amphotericin B (SI = 140).
Graphical abstractSynthesis and biological evaluation of 4-arylcoumarins as antiprotozoal agents were investigated. The 4-(3,4-dimethoxyphenyl)-6,7-dimethoxycoumarin was found to exhibit a potent activity on Leishmania donovani amastigotes with a selectivity index (SI = 265) twice than amphotericin B (SI = 140).Figure optionsDownload full-size imageDownload as PowerPoint slide
