| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397810 | European Journal of Medicinal Chemistry | 2010 | 7 Pages |
The reaction of 1,3-cyclohexadione with 2-aminobenzoic acid has produced the 2-(3-oxocyclohex-1-enyl)benzoic acid (HOBz). Subsequent reactions of the ligand with organotin chlorides led to [Me2Sn(OBz)O]2 (1), [Bu2Sn(OBz)O]2 (2), [Ph2Sn(OBz)O]2 (3), [Me3Sn(OBz)] (4), [Bu3Sn(OBz)] (5) and [Ph3Sn(OBz)] (6). All complexes have been fully characterized. In addition the structure of complexes (2) and (4) have been authenticated by X-ray crystallography. The biological activity of all derivatives has been screened against Cryptococcus neoformans and Candida albicans. In addition we have performed toxicological testes employing human kidney cell. The complexes (3), (5) and (6) displayed the best values of inhibition of the fungus growing, superior to ketoconazole. Compound (5) presented promising results in view of the antifungal and cytotoxicity assays.
Graphical abstractFollowing our interest in the biological aspects of organotin chemistry we have obtained new organotin complexes with 2-(3-oxocyclohex-1-enyl)benzoic. The biological activities of the resultant products were assayed.Figure optionsDownload full-size imageDownload as PowerPoint slide
