Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1397837 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
β-Thujaplicin (hinokitiol or 2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), a natural tropolone, shows numerous activities while its synthetic analogues were found to exhibit anticancer and anti-ischemic activity. However, the ability of tropolone derivatives to protect neuronal cells from oxidative stress-induced cell damage has not been studied so far. As an ongoing effort toward highly effective antioxidants with potential neuroprotective activity, we have synthesized 7-substituted derivatives of β-thujaplicin and its methoxy analogue. The substituents were heterocycles (piperazine, morpholine) or heteroaromatics (triazoles, pyridine). Only the piperazine derivatives of β-thujaplicin were able to protect HT22 hippocampal neurons from oxidative stress-induced cell death.
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