Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety

In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans.

Graphical abstractIn the present investigation, a new series of 1,3,4-oxadiazoles bearing 2-flouro 4-methoxy phenyl moiety were synthesized, characterized and their antimicrobial studies were performed. Few of the compounds showed significant antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide