| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397877 | European Journal of Medicinal Chemistry | 2009 | 7 Pages |
Abstract
Arachidonyl and linoleyl sulfamide derivatives have been synthesized and their potential cannabimimetic properties evaluated in in vitro functional and binding assays. Replacement of the ethanolamide moiety of anandamide by –CH2NHSO2NH–R considerably reduces the CB1 receptor activity and only some of the compounds showed modest cannabinoid properties in binding assays. The new compounds were also tested as inhibitors of the FAAH enzyme but were inactive.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carolina Cano, Juan Antonio Páez, Pilar Goya, Antonia Serrano, Javier Pavón, Fernando Rodríguez de Fonseca, Margarita Suardíaz, María Isabel Martín,