Synthesis and antimicrobial activity of some new N-acyl substituted phenothiazines

A series of 2-substituted N-acylphenothiazines were synthesized by using imides, N-carboxymethyl imides and the structures of these newly synthesized compounds were confirmed by spectral and elemental analyses. All new compounds were tested for their antibacterial and antifungal activities. Some compounds showed promising antibacterial and antifungal activities.

Graphical abstractA series of 2-substituted N-acylphenothiazines were synthesized by using imides, N-carboxymethyl imides and tested for their antimicrobial activities. Some compounds showed very good antibacterial and antifungal activities. R: a – H, b – Cl, c – CF3, d – COCH3Figure optionsDownload full-size imageDownload as PowerPoint slide