| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397917 | European Journal of Medicinal Chemistry | 2009 | 7 Pages |
The antifungal activity of some known unsaturated Mannich ketones and their amino alcohols has been reported and the mechanism of antifungal action has been studied. The inhibition of the fungal ergosterol, chitin, protein synthesis and pseudohypha formation was investigated. According to our results, Mannich ketones can influence the development of pseudohyphae of Candida albicans strains. In addition, they are able to induce significant changes in the protein composition of this fungal strain. Some of our Mannich ketones have shown inhibitory effect on the fungal chitin synthase enzyme. QSAR studies were also carried out.
Graphical abstractThe antifungal activity and the mechanism of action of some unsaturated Mannich ketones were investigated studying the inhibition of the fungal ergosterol, chitin, protein synthesis and pseudohypha formation.Figure optionsDownload full-size imageDownload as PowerPoint slide
