| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1397967 | European Journal of Medicinal Chemistry | 2009 | 5 Pages |
Abstract
Rebeccamycin derivative 1 bearing a sugar moiety linked to both indole nitrogens and an amino substituent on the carbohydrate unit was synthesized in three steps from the bacterial metabolite. This compound was found to be a highly potent checkpoint kinase 1 inhibitor with an IC50 value of 2.8 nM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabrice Anizon, Roy M. Golsteyn, Stéphane Léonce, Bruno Pfeiffer, Michelle Prudhomme,