Possible anticancer agents: QSAR analogs of glutamamide: Synthesis and pharmacological activity of 1,5-N,N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides

Based on our earlier QSAR prediction, a series of QSAR analogs of 1,5-N,N′-disubstituted-2-(substituted benzenesulphonyl) glutamamides were synthesized, pharmacologically evaluated and QSAR analysis of these compounds was performed. The study showed importance of particular atoms in dispersive interaction of the compounds with the enzymes, as well as the substitution patterns required for improved activity which may offer an opportunity for further tailoring of these analogs for an active member.