Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero Diels–Alder reaction and evaluation of antimicrobial activity

A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels–Alder reaction of α-nitrosoolefins with alkenes. α-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10–35 μg ml−1 for bacteria and 10–40 μg ml−1 for fungi.

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