Synthesis and antihypertensive effects of new methylthiomorpholinphenol derivatives

We present in this work the synthesis and cardiovascular effects of new methylthiomorpholine compounds and they were compared with cardiovascular drugs such as captopril, losartan and omapatrilat.

Graphical abstractNew methylthiomorpholinphenol (example 1) compounds were prepared from phenol derivatives and thiomorpholine and they present cardiovascular activity. The study was made comparing with drugs such as captopril, omapatrilat and losartan. Those compounds do not reduce blood pressure in a sudden manner as in the case of vasodilatations and β-adrenergic blockers, angiotensin-converting enzyme inhibitors (ACE), receptors AT1 antagonists, and neutral endopeptidase inhibitors.Figure optionsDownload full-size imageDownload as PowerPoint slide