Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1398174 | European Journal of Medicinal Chemistry | 2007 | 8 Pages |
Abstract
The synthesis of 1-aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones by cyclization of 4-[(dimethylamino)methylidene]-3,4-dihydro-1H-[1]benzazepine-2,5-dione with arylhydrazines is reported. When tested on a panel of human cancer cell lines, the title compounds showed antiproliferative activity and a characteristic selectivity pattern of growth inhibition. Although structurally akin to established kinase inhibitors, the new compounds did not exhibit noteworthy inhibitory activity when tested on an array of cancer-related kinases.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Simone Kohfeld, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick,