| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1398181 | European Journal of Medicinal Chemistry | 2007 | 8 Pages |
Several compounds of great pharmacological interest contain the triazole and imidazole rings. In order to find new drugs with antileishmanial activity we have synthesized and evaluated new imidazole and triazole compounds carrying either the carbaldehyde or the difluoromethylene functionalities against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Our results show that the introduction of the difluoromethylene moieties has turned the inactive carbaldehydes into active antileishmanial compounds.
Graphical abstractWe have synthesized and evaluated new imidazole and triazole compounds against promastigote forms of Leishmania amazonensis. Among the compounds tested difluoromethylene azoles 4b and 8f have inhibited the parasite growth significantly. Figure optionsDownload full-size imageDownload as PowerPoint slide
