Article ID Journal Published Year Pages File Type
1398191 European Journal of Medicinal Chemistry 2007 8 Pages PDF
Abstract

Some new platinum (IV) and palladium (II) thiodiamine complexes of type [Pt(L)2Cl2] and [Pd(L)Cl2], [where, L = (cyclohexyl-N-thio)-1,2-ethylenediamine (L1) and (cyclohexyl-N-thio)-1,3-propanediamine (L2)] have been synthesized. The thiodiamines coordinate as a bidentate N–S ligand. The synthesized platinum (IV) and palladium (II) complexes of the thiodiamines were characterized by elemental analysis, IR, mass, electronic and 1H NMR spectroscopic studies. These complexes were also screened for cytotoxicity, in vitro antifungal and in vitro antibacterial activities. Thermodynamic parameters such as activation energy (Ea), apparent activation entropy (S#) and enthalpy change (ΔH) for the dehydration and decomposition reactions of one complex has also been evaluated.

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