Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists

Article ID	Journal	Published Year	Pages	File Type
1398725	European Journal of Medicinal Chemistry	2015	14 Pages	PDF

Keywords

FMOC BzATP IL-1β HRMS NaHCO3 DMF EtBr ACN TBDMS EtOH P2X7R NADP DCM KN-62 Fluorenylmethyloxycarbonyl LiBr FBS 2-(2-methoxy-4-nitrophenyl)-3-(4-nitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium, monosodium salt SAR LPS DMEM KN62 HEPES WST-8 AcCl EDC 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid DMSO Dulbecco's modified Eagle Medium adenosine-5′-triphosphate ATP Antagonists Ethanol ethidium bromide Acetonitrile acetyl chloride inflammation Interleukin-1β Fast atom bombardment tert-butyldimethylsilyl triethylamine ELISA Enzyme-linked immunosorbent assay Room temperature dimethylformamide Dichloromethane Dimethyl sulfoxide Structure–activity relationship Structure–activity relationships fetal bovine serum high-resolution mass spectrometry Fab Lithium bromide lipopolysaccharide NAH nicotinamide adenine dinucleotide phosphate Sodium hydride TEA Sodium hydrogen carbonate high-pressure liquid chromatography HPLC P2X7 receptor

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists

Authors

Jin-Hee Park, Ga-Eun Lee, So-Deok Lee, Hyojin Ko, Yong-Chul Kim,