| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1398891 | European Journal of Medicinal Chemistry | 2014 | 5 Pages |
•Benzothiazole hydrazones were synthesized.•Antiproliferative activity of these compounds was evaluated.•Compounds 3n and 3o showed significant cytotoxicity against leukemia (HL-60).•Compounds 3o and 3p exhibited cytotoxicity against three cancer cell lines.•Benzothiazole hydrazones bear hydroxyl groups may have a good oral biodisponibility.
Benzothiazole hydrazones have been synthesized and evaluated for their in vitro antiproliferative activity against three human cancer cell lines: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). The good cytotoxicity for the three cancer cell lines and theoretical profile of compounds 3o and 3p pointed them as promising lead molecules for anticancer drug design.
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