Ultrasound promoted one pot synthesis of novel fluorescent triazolyl spirocyclic oxindoles using DBU based task specific ionic liquids and their antimicrobial activity

•Synthesis of novel 1,2,3-triazole-spirocyclic oxindoles is described.•Antibacterial, antifungal activity of all compounds was evaluated.•Compounds showed good to moderate antimicrobial activity.•Docking studies were also performed.

Spirocyclic oxindoles and triazolyl derivatives posses remarkable biological activities. In present work, we have described an efficient one pot four-component domino reaction of 1-(prop-2-ynyl)indoline-2,3-dione, cyclic 1,3-diketones, malononitrile and various aryl azides in DBU based ionic liquids [DBU-H]OAc and [DBU-Bu]OH under ultrasonic irradiation for the construction of heterocycles, comprising spiro-oxindole, 2-amino-4H-pyran, and 1,2,3-triazoles substructures. The antimicrobial activity of all compounds has been investigated against six microbial strains. All compounds showed good antimicrobial activity. All newly synthesized compounds exhibit fluorescence in methanol with large stoke shift.

Graphical abstractThe antimicrobial activity of all new fluorescent spirocyclic oxindole triazolyl derivatives has been investigated against six microbial strains. All compounds showed good antimicrobial activity.Figure optionsDownload full-size imageDownload as PowerPoint slide