| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399089 | European Journal of Medicinal Chemistry | 2013 | 8 Pages |
•A new series of ferrocene tagged multi-functionalized 1,4-DHPMs is synthesized.•The synthesized compounds exhibited remarkable anti-breast cancer activity.•The structures of the compounds were established on basis of analytical and spectral data.
A novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines is synthesized by base catalyzed cyclocondensation between ferrocenyl chalcones and amidines. The structures of synthesized compounds were established on the basis of 1H NMR, 13C NMR, FTIR spectroscopy as well as by mass spectrometry. The compounds were evaluated for in vitro anticancer activity. The most active compounds from the series displayed GI50 value equal to doxorubicin against the strain of human breast cancer cell line MDA-MB-435.
Graphical abstractA novel series of ferrocene tagged multi-functionalized 1,4-dihydropyrimidines have been synthesized and fully characterized. The synthesized compounds showed significant cytotoxicity against human breast cancer cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
