| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399119 | European Journal of Medicinal Chemistry | 2013 | 6 Pages |
•Successful novel amalgamation of piperidine, triazole and thieno pyridine.•Evaluation of antifungal activity which revealed interesting data.•Specificity of compounds toward fungal strains.•Role of chain length and sulphonyl group.
It is the first report of the novel amalgamation of 1,2,3-triazoles, piperidines, thieno pyridine rings and evaluation of their antifungal activity. The synthesized compounds showed interesting moderate to good antifungal activity, wherein they were able to discriminate between the two species Aspergillus flavus and Aspergillus niger of the same genus. In addition, the main highlight of this series is the sensitivity of the fungal strain Cryptococcus neoformans to the compounds having p-chlorobenzoyl (9h), methane sulfonyl (9i) and p-methylbenzene sulfonyl (9j) attached to the piperazine nitrogen.
Graphical abstractIt is the first report for the novel amalgamation of 1,2,3-triazoles, piperidines, thieno pyridine rings and evaluation of their antifungal activity, revealing specificity toward fungal strains.Figure optionsDownload full-size imageDownload as PowerPoint slide
