Triazolothiadiazoles and triazolothiadiazines – Biologically attractive scaffolds

Contemporary medicinal chemistry faces diverse challenges from several directions, including the need for both potency and specificity of any therapeutic agent. Therefore, in the present perspective, the triazolothiadiazoles and triazolothiadiazines with broad spectrum biological profile have matured into indispensable heterocyclic scaffolds. This review article is an effort to summarize medicinal chemistry investigations over the last decade, in search for new N-bridged heterocycles which can be a rich source of promising biological activities.

Graphical abstractThis review article highlights comprehensively the triazolothiadiazoles and traizolothiadiazines as central structural motifs of numerous compounds with activities of relevance to different areas.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The article features the biological activities of triazolothiadiazoles and thiadiazines. ► Various synthetic methodologies leading to target molecules have been reported. ► Compounds with potent biological potential have been identified. ► SAR of the synthesized analogs may serve as a tool for the development of new leads. ► The recent progress speculates further design and developments in this research area.