| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399197 | European Journal of Medicinal Chemistry | 2013 | 11 Pages |
Abstract
⺠Novel cyclic ureidopeptides analogues of dermorphin/deltorphin were synthesized. ⺠Their in vivo antinociceptive activity and resistance to proteolysis were evaluated. ⺠N-substituted amides with D-amino acid showed extremely high proteolytic stability. ⺠Analogue 1 showed significant antinociceptive effect after systemic applications.
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Authors
Krzysztof BaÅkowski, Ewa Witkowska, Olga M. Michalak, Katarzyna Sidoryk, Ewa Szymanek, Bożena Antkowiak, MaÅgorzata Paluch, Katarzyna E. Filip, Marek Cebrat, Bartosz Setner, Zbigniew Szewczuk, Piotr Stefanowicz, Piotr Cmoch, Jan Izdebski,