| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399259 | European Journal of Medicinal Chemistry | 2013 | 6 Pages |
Abstract
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC50 of 7.8 μM.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► New substituted 1,4-naphthoquinones were synthesized. ► The products exhibited substantial activity against T. cruzi. ► The more active compound 9 showed a IC50 of 7.8 μM against T. cruzi.
Related Topics
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Authors
Adriano Olímpio da Silva, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima,