Discovery of coumarin–monastrol hybrid as potential antibreast tumor-specific agent

Development of new, targeted antibreast cancer drug which can treat both the hormone receptor (positive and negative) breast cancers is a very challenging task. The concept of molecular hybridization led us to discover a novel class of coumarin–monastrol hybrid, as a novel breast cancer agent which selectively induce apoptosis in both primary and metastatic breast cancer cell lines.

Graphical abstractA novel series of coumarin–monastrol hybrids were synthesized and evaluated for their in vitro anticancer activity, the compound 10 exhibited selective and potent antibreast cancer activity.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Discovery of coumarin–monastrol hybrids with antibreast cancer activity. ► Compound 10 inhibits the proliferation of both primary and metastatic breast cancer cells. ► Compound 10 induces apoptosis in breast cancer cells and arrests cell cycle at G1 phase.