| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399412 | European Journal of Medicinal Chemistry | 2012 | 7 Pages |
Abstract
⺠Dimeric 3,5-bis(benzylidene)-4-piperidones 1 are a novel class of potent cytotoxic agents. ⺠Demonstrate noteworthy tumour-selective toxicities compared to a number of normal cells. ⺠Mode of action includes apoptosis, PARP cleavage and G2/M phase blockage of the cell cycle. ⺠Potent multidrug-resistant reversal agents.
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Authors
Swagatika Das, Umashankar Das, Hiroshi Sakagami, Naoki Umemura, Shoko Iwamoto, Tomohiko Matsuta, Masami Kawase, Joseph Molnár, Julianna Serly, Dennis K.J. Gorecki, Jonathan R. Dimmock,