| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399484 | European Journal of Medicinal Chemistry | 2010 | 7 Pages |
Abstract
A series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-β-carboline derivatives has been synthesized and evaluated for antileishmanial activity against Leishmania donovani. Compound 8 exhibited best antileishmanial activity with IC50 value of 1.93 μg/ml against amastigotes, high selectivity index, and was more active than reference drugs sodium stilbogluconate and pentamidine.
Graphical abstractA novel series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-β-carbolines has been synthesized and evaluated for their antileishmanial activity against Leishmania donovani.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ravi Kumar, Shahnawaz Khan, Aditya Verma, Saumya Srivastava, Preeti Viswakarma, Suman Gupta, Sanjeev Meena, Neetu Singh, Jayanta Sarkar, Prem M.S. Chauhan,