| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399496 | European Journal of Medicinal Chemistry | 2010 | 5 Pages |
Abstract
A series of pyrazine-2-carboxylic acid hydrazide derivatives were synthesized and screened for their activity against Mycobacterium tuberculosis. The results show that pyrazine-2-carboxylic acid hydrazide–hydrazone derivatives 3a–l were less active than pyrazinamide. In contrast, the N4-ethyl-N1-pyrazinoyl-thiosemicarbazide 4 showed the highest activity against M. tuberculosis H37Rv (IC90 = 16.87 μg/mL). Details of the structure–activity and structure–cytotoxicity relationships are discussed.
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Related Topics
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Organic Chemistry
Authors
Mohamed Abdel-Aziz, Hamdy M. Abdel-Rahman,