Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1399504 | European Journal of Medicinal Chemistry | 2010 | 6 Pages |
Abstract
In an attempt to develop potent and selective antitumor agents, a series of liquiritigenin thiosemicarbazone derivatives were designed and synthesized. The cytotoxicities of these compounds were evaluated in vitro against K562, DU-145, SGC-7901, HCT-116 and Hela cell lines. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward K562 and DU-145 cells. From the structure–activity relationships we may conclude that the introduction of a thiosemicarbazone functional group at the 4-position in the skeleton of liquiritigenin is associated with an increase in cytotoxicity.
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Related Topics
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Organic Chemistry
Authors
Kun Hu, Ze-hua Yang, Sha-Sha Pan, Hua-jin Xu, Jie Ren,