| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399592 | European Journal of Medicinal Chemistry | 2010 | 9 Pages |
Abstract
A novel class of potent aminopeptidase N inhibitors with 3-amino-cyclic-imide scaffold is described. The preliminary biological test revealed that all the compounds displayed high specific inhibitory activity against aminopeptidase N compared with previous work because of the existence of free amino group. Compounds containing hydroxamate group are more potent than carboxyl and ester derivatives. Compound 13f potentially inhibited APN activity with IC50 value of 1.8 μM and displayed specific activity profiles in cells assay and in vivo anti-metastasis assay.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qianbin Li, Hao Fang, Xuejian Wang, Wenfang Xu,