Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines

5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2–10. Furthermore, the preparation of sugar hydrazone derivatives 11a,b, 12a,b and their annelated C-nucleosides 13a,b was described. Some of the prepared products revealed promising antiviral activity against herpes simplex virus type-1 (HSV-1) in comparison to Acyclovir as a control.

Graphical abstractPyrazolo[3,4-d]pyrimidine derivatives are interesting compounds with diverse chemical properties and antiviral activities. Herein, the synthesis and antiviral evaluation of some new pyrazoles and pyrazolo[3,4-d]pyrimidines are described.Figure optionsDownload full-size imageDownload as PowerPoint slide