Convenient access to 1,3,4-trisubstituted pyrazoles carrying 5-nitrothiophene moiety via 1,3-dipolar cycloaddition of sydnones with acetylenic ketones and their antimicrobial evaluation

Novel 1-aryl-3-(5-nitro-2-thienyl)-4-aroyl-pyrazoles 7 have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones 3 with 1-aryl-3-(5-nitro-2-thienyl)-2-propyn-1-ones 6. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. They were also screened for their antibacterial and antifungal activities against a variety of microorganisms and the results of such studies have been discussed in this article.

Graphical abstractNovel 1-aryl-4-aroyl-3-(5-nitro-2-thienyl) pyrazoles have been synthesized by the 1,3-dipolar cycloaddition of 3-arylsydnones with 1-aryl-3-(5-nitro-2-thienyl)-2-propyne-1-ones.Figure optionsDownload full-size imageDownload as PowerPoint slide