Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1399713 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
Abstract
In this paper we discuss the anticancer activity of acetylsalicylic acid with oligo(3-hydroxybutanoate) conjugates, their characteristics and in vitro biological evaluation. Acetylsalicylic acid (aspirin) attached via hydrolysable ester bonds to non-toxic well-defined 3-hydroxybutanoic acid oligomers shows novel method of drug modification.The resulting conjugates were more effective than aspirin in growth inhibition of human colon adenocarcinoma cells HT-29 and human colon carcinoma cells HCT 116 in vitro. Treatment of rats with doses as high as 2 g of the conjugate (equivalent to 0.6 g of pure aspirin) per kg of body weight did not exhibit toxic effects.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Maria Juzwa, Aleksandra Rusin, Barbara Zawidlak-Węgrzyńska, Zdzisław Krawczyk, Ilona Obara, Zbigniew Jedliński,