| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399755 | European Journal of Medicinal Chemistry | 2008 | 8 Pages |
Abstract
A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the antiproliferation test or in the HIV anti-integrase test.
Graphical abstractA series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the antiproliferation test or in the HIV anti-integrase test.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabrice Bailly, Clémence Queffélec, Gladys Mbemba, Jean-François Mouscadet, Nicole Pommery, Jean Pommery, Jean-Pierre Hénichart, Philippe Cotelle,