| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399767 | European Journal of Medicinal Chemistry | 2008 | 6 Pages |
Abstract
The first crystal structure of a thrombin-inhibitor (discovered by a computer-assisted multiparameter optimization process, CADDIS®) complex, where an uncharged inhibitor residue makes hydrogen bonds within the thrombin S1 pocket.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rainer Friedrich, Daniel Riester, Peter Göttig, Marcel Thürk, Andreas Schwienhorst, Wolfram Bode,