| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399882 | European Journal of Medicinal Chemistry | 2008 | 4 Pages |
Abstract
The synthesis and evaluation of 2,5-bis[4-(N-ethoxycarbonyl-N′-isopropyl)amidinophenyl]furan, 2,5-bis[4-(N-2,2,2-trichloroethoxycarbonyl-N′-isopropyl)amidinophenyl]furan and 2,5-bis[4-(N-cyclopentyl-N′-2,2,2-trichloroethoxycarbonyl)amidinophenyl]furan as prodrugs of bis-N-alkylamidines are reported. The results show that the bis-2,2,2-trichloroethyl carbamates function effectively in a rat model for Pneumocystis pneumonia.
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Related Topics
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Authors
Syed M. Rahmathullah, Richard R. Tidwell, Susan K. Jones, James E. Hall, David W. Boykin,