| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399918 | European Journal of Medicinal Chemistry | 2007 | 8 Pages |
Abstract
The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-l-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARα transactivation as compared to PPARγ. Molecular docking analysis was carried out to study their important interactions with the active site of PPARα.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rakesh Kumar, Uma Ramachandran, Suryaprakash Raichur, Ranjan Chakrabarti, Rahul Jain,