Chemotherapy of leishmaniasis Part VI: Synthesis and bioevaluation of some novel terpenyl S,N- and N,N-acetals

Some novel terpene based oxoketene S,N-acetals 2(a–g) and N,N-acetals 3(a–c) have been synthesized from oxoketene dithioacetal 1. The compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model.

Graphical abstractSome novel terpene based oxoketene S,N-acetals 2(a–g) and N,N-acetals 3(a–c) have been synthesized from oxoketene dithioacetal 1 and the compounds were screened for their in vivo antileishmanial activity. Some of the compounds showed 50–70% inhibition in the hamster model.Figure optionsDownload full-size imageDownload as PowerPoint slide