| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399938 | European Journal of Medicinal Chemistry | 2007 | 9 Pages |
Abstract
Two series of 1,2,4-triazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles derived from three selected arylpropionic acids namely, ibuprofen, flurbiprofen and naproxen, were synthesized and evaluated for anti-inflammatory activity and ulcerogenic potential. All the tested compounds exhibited anti-inflammatory activity comparable to that of hydrocortisone. Compared to ibuprofen, however, all the tested compounds displayed more potent anti-inflammatory activity. Compounds tested for ulcerogenicity showed no or minimal ulcerogenic effect compared to indomethacin.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kamel A. Metwally, Shada H. Yaseen, El-Sayed M. Lashine, Hassan M. El-Fayomi, Mohamed E. El-Sadek,