Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1399947 | European Journal of Medicinal Chemistry | 2007 | 5 Pages |
Abstract
An efficient synthesis of dialkylsubstituted maleic anhydrides 1a–j is described. The inhibitory potential of these original anhydride derivatives was tested toward the three human isoforms A, B and C of dual specific phosphatases Cdc25. A micromolar range inhibition of Cdc25s was observed with the maleic anhydrides bearing simple alkyl side chains longer than C9, to reach the optimal activity with a C17 chain length.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laurent Brault, Mickaël Denancé, Estelle Banaszak, Souhayla El Maadidi, Eric Battaglia, Denyse Bagrel, Mohammad Samadi,