| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399985 | European Journal of Medicinal Chemistry | 2006 | 5 Pages |
Abstract
A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5′-dinitro-2-(2,3-diaza-4-(2′-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
D.G. Rando, A.C. Doriguetto, C.H. Tomich de Paula da Silva, J. Ellena, D.N. Sato, C.Q.F. Leite, E.A. Varanda, E.I. Ferreira,