| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1399986 | European Journal of Medicinal Chemistry | 2006 | 9 Pages |
Abstract
The synthesis of a new series of 1β-methylcarbapenems having pyrrolidine and piperidine moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIb) having hydroxypyrrolidine moiety showed the most potent antibacterial activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
H.C. Jeon, J.-W. Kim, J.H. Hong, J.-H. Cho, C.-H. Oh,