Synthesis of stilbene derivatives with inhibition of SARS coronavirus replication

Stilbene derivatives have wide range of activities. In an effort to find other potential activities of this kind of compounds, 17 derivatives, including resveratrol, were synthesized. Twelve of them were evaluated for their antiviral potential against severe acute respiratory syndrome (SARS)-CoV-induced cytopathicity in Vero E6 cell culture. The result showed that SARS virus was totally inhibited by compounds 17 and 19 ( ≤ 0.5 mg ml–1) and no significant cytotoxic effects were observed in vitro.

Graphical abstractSeventeen stilbene derivatives were synthesized and 12 of them were evaluated for their antiviral potential against SARS-CoV-induced cytopathicity in Vero E6 cell culture. Compound 17 and 19 showed viral inhibition.Figure optionsDownload full-size imageDownload as PowerPoint slide