Article ID Journal Published Year Pages File Type
1400078 European Journal of Medicinal Chemistry 2006 9 Pages PDF
Abstract

The synthesis of a series of α-methylene-γ-butyrolactones (compounds 4a, 4b, 6–12, 16, 17) and α,β-unsaturated-δ-lactones (compounds 19−23, 25, 26) starting from 4,4-dimethyldihydrofuran-2,3-dione (1) has been described. Their chemical structures were assigned by spectroscopic evidence. These new compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with their IC50 values ranging from 0.88 to > 20.00 μM.

Graphical abstractThe synthesis of a series of α-methylene-γ-butyrolactones and α, β-unsaturated-δ-lactones has been described. Their chemical structures were assigned by spectroscopic evidence. The compounds exhibited significantly different antiproliferative properties against cultured human tumor cell lines with IC50 values ranging from 0.88 to > 20.00 μM.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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