| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1400949 | Journal of Molecular Structure | 2016 | 4 Pages |
Abstract
•N1-alkylation of imidazolidin-4-ones under basic conditions.•Chemical stabilization of imidazolidin-4-one ring.•New peptidomimetic derivatives of antimalarial drug primaquine.
N1-unsubstituted imidazolidin-4-ones of primaquine (PQ) can be stabilized by N1-alkylation under basic conditions. Here we report the development, with our conditions, of peptidomimetic derivatives of PQ with l-amino acid and alkyl derivatives. The new derivatives represent potential new therapeutics for use against protozoan parasites, through enzymatic protection of aminopeptidases.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nuno Vale, Patrícia Figueiredo,